The episode starts with Chuck, who is seen resting on a bed, completely bandaged. He suddenly has the urge to pee, but since he couldn't reach his potty, he has to move along his bed little by little. A fly starts bugging him repeatedly, making him pee himself. Now completely enraged, Chuck frees himself from the bandages and squashes the fly, but soon after, the fly heals itself and flies inside a hole on a wall. Chuck peeks inside the hole, and suddenly, thousands of flies come out of the hole and form a giant hand.
The giant hand starts squashing Chuck repeatedly. It then carries him to the kitchen and locks him up inside the microwave. The flies gesture a farewell and turn the microwave on. The red devil living inside Chuck's head comes out of him via his tail zipper, and along with Chuck, tries opening the microwave, without any luck. A few seconds later, Chuck and the red devil explode. In the end, Chuck is seen healing himself from the inside out while floating.
After being microwaved, Chuck reforms itself similar to Watchmen's Dr. Manhattan.
The scene where Chuck punches a fly on the wall, and gets hit with a constant stream of flies, is a parody of a scene from Evil Dead 2, where Ash gets sprayed in the face with a stream of blood coming from a hole in the wall.